Fig. 4: Progerin causes the accumulation of the A-type nuclear lamins in the thoracic aorta. | Cell Death & Disease

Fig. 4: Progerin causes the accumulation of the A-type nuclear lamins in the thoracic aorta.

From: The accumulation of progerin underlies the loss of aortic smooth muscle cells in Hutchinson-Gilford progeria syndrome

Fig. 4

A Western blot comparing the expression of lamin A, lamin C, farnesyl-prelamin A, progerin, and lamin B1 in aortas from 5- and 14-week-old LmnaG609G/+, Zmpste24−/−, and Zmpste24−/−LmnaG609G/+ mice. Tubulin was measured as a loading control. The ages and mouse IDs are shown above each sample. B Bar graph showing lamin A, progerin, and lamin C expression (relative to tubulin) in aortas from young and old LmnaG609G/+ mice. Mean ± SEM (n = 4 mice/group). Student’s t test. **P < 0.01. ***P < 0.001. C Bar graph showing farnesyl-prelamin A (f-PreA) and lamin C expression (relative to tubulin) in aortas from young and old Zmpste24−/− mice. Mean ± SEM (n = 4 mice/group). Student’s t test. ns, not significant. D Bar graph showing f-PreA, progerin, and lamin C expression (relative to tubulin) in aortas from young and old Zmpste24−/−LmnaG609G/+ mice. Mean ± SEM (n = 4 mice/group). Student’s t test. **P < 0.01. ***P < 0.001. ****P < 0.0001. E Bar graph showing lamin B1 expression (relative to tubulin) in aortas from young and old LmnaG609G/+, Zmpste24−/−, and Zmpste24−/−LmnaG609G/+ mice. Mean ± SEM (n = 4 mice/group). Student’s t test. **P < 0.01.

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