Fig. 4: Reduced tumorigenic and metastastatic capacity of transdifferentiated HT144 melanoma cells in vivo.
From: Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion
A, B Schematic overview of the in vivo experimental procedure. C Mice injected with transdifferentiated cells exhibit a longer survival time than those injected with the parental melanoma cells. D Comparison of size and weight of tumors derived from transdifferentiated or parental melanoma cells upon subcutaneous injection into NSG mice. E Comparison of the number of visible metastases and liver weight upon intravenous injection of transdifferentiated parental melanoma cells into NSG mice. F Comparison of the number of visible metastases and lung weight upon intravenous injection of transdifferentiated or parental melanoma cells into NSG mice.
