Fig. 7: Cholesterol-conjugated HOXC8 siRNA suppresses tumor growth of A549 cells. | Cell Death & Disease

Fig. 7: Cholesterol-conjugated HOXC8 siRNA suppresses tumor growth of A549 cells.

From: HOXC8 impacts lung tumorigenesis by preventing pyroptotic cell death through the suppression of caspase-1 expression

Fig. 7

A A549 cells (106 cells/mouse) in Matrigel (mixed in 1:1 ratio) were injected to athymic nude mice for 3 week followed by administering 1 OD Chol-Scrambled sequence (Chol-NC) or Chol-HOXC8 siRNA (Chol-siHOXC8) directly on established tumors once every three days for 3 weeks. Rate of tumor development was determined by measuring tumor volume once every three days. Data are means ± SEM (n = 5). **P < 0.01 (Chol-siHOXC8 vs Chol-NC). B Image of tumors excised form tumor-bearing mice treated with Chol-NC or Chol-siHOXC8. C Weight of tumors excised from tumor-bearing mice treated with Chol-NC) or Chol-siHOXC8). Data are means ± SEM. **P < 0.01. D Representative pictures of IHC staining on HOXC8, caspase-1, Ki67 and cleaved caspase-3 in tumor tissues.

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