Fig. 6: ILF3 and SLC3A2 are co-expressed in CRC tissues. | Cell Death & Disease

Fig. 6: ILF3 and SLC3A2 are co-expressed in CRC tissues.

From: ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA

Fig. 6: ILF3 and SLC3A2 are co-expressed in CRC tissues.The alternative text for this image may have been generated using AI.

A The GSE41328 and GSE74604 datasets summarize the expression levels of SLC3A2 mRNA in colon adenocarcinoma and normal tissues. B Representative IHC images showing SLC3A2 expression in colorectal cancer (CRC) and adjacent normal tissues. Scale bar = 20 μm. C Statistical analysis of the positive and strongly positive rates of SLC3A2 protein expression in CRC and adjacent normal tissues based on immunohistochemical (IHC) staining results, P < 0.01. D Correlation analysis of SLC3A2 protein expression levels with tumor size (P = 0.036) and lymph node metastasis (P = 0.043). E Kaplan–Meier survival curve showing overall survival based on SLC3A2 expression levels obtained from KM-plotter database (Affymetrix ID = 200924_s_at). F Overall survival curves for SLC3A2 protein expression profiles. G, H IHC staining experiments showing that ILF3 and SLC3A2 staining areas co-localized (G), and their IHC staining scores were positively correlated (H). I Western blot analysis of SLC3A2 protein expression in 14 paired CRC and adjacent normal tissue samples. J Correlation analysis of ILF3 and SLC3A2 protein expression levels detected by western blot, quantified using Image J. K Representative multiplex immunostaining image of a CRC tissue sample (keratin, red; ILF3, green; SLC3A2, yellow; DAPI, blue). Keratin was used to label tumor cells, and DAPI was used to highlight nuclei.

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