Fig. 4: Reclustering of T and NK cells identified in 14 samples from 5 patients with differing axillary responses after NAC (part 2). | Cell Death & Disease

Fig. 4: Reclustering of T and NK cells identified in 14 samples from 5 patients with differing axillary responses after NAC (part 2).

From: Multi-omics prediction of axillary treatment response and tumour microenvironment alterations in lymph node-positive luminal breast cancer

Fig. 4: Reclustering of T and NK cells identified in 14 samples from 5 patients with differing axillary responses after NAC (part 2).

A, B GO enrichment analysis showed that the CD4NaiveT_NR4A1 and CD4NaiveT_FOS subclusters in the pLCR_T group upregulated multiple immune-related pathways, including T cell activation, lymphocyte differentiation, and response to tumour necrosis factor. C Expression levels of typical marker genes in the subclusters. D Cytotoxicity scores of different subclusters of T and NK cells. E Differences in exhaustion scores between the subgroups. F Exhaustion scores of different subclusters of T and NK cells. G Differences in pro-inflammatory scores between the subgroups. H Differences in T cell activation scores between the subgroups. I Differences in cytotoxicity scores between the subgroups. BP biological process, CC cellular component, GO Gene Ontology, MF molecular function, NAC neoadjuvant chemotherapy, NK natural killer.

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