Fig. 3: JQ-1 administration alleviates MI-induced cardiac injury in mice. | Cell Death & Disease

Fig. 3: JQ-1 administration alleviates MI-induced cardiac injury in mice.

From: (+)-JQ-1 alleviates cardiac injury in myocardial infarction by inhibiting ferroptosis through the NAMPT/SIRT1 pathway

Fig. 3: JQ-1 administration alleviates MI-induced cardiac injury in mice.The alternative text for this image may have been generated using AI.

A Experimental protocol showing JQ-1 administration strategy in mice with MI. JQ-1 (50 mg/kg) or equivalent vehicle was injected intraperitoneally 2 days before MI. B Heart rate of JQ-1-administrated mice after 28 days of MI (n = 6). C Representative M-mode echocardiography images in mice 28 days post MI treated with JQ-1. D Effect of JQ-1 administration on LVEF and LVFS at indicated time points (n = 6). E Effect of JQ-1 administration on heart weight to tibial length ratios 28 days after MI (n = 6). F Representative H&E and Masson’s trichrome stained heart sections from mice 28 days post MI treated with JQ-1. Scale bars, 1 mm. Quantification of the fibrosis area (G) and infarct area (H) of the myocardium from mice 28 days post MI with JQ-1 administration (n = 6). I Effect of JQ-1 on Nppa, Nppb, and Myh7 mRNA expression in the cardiac tissue from mice 1 day after MI (n = 6). Effect of JQ-1 on cardiac GSH/GSSG ratios (J) and MDA levels (K) from mice 1 day after MI (n = 6). L Analysis of Ptgs2 and Hmox1 mRNA levels in the cardiac tissue from mice 1 day post-MI, (n = 3). Representative immunoblot images (M) and quantitative analysis (N) of the relative GPX4 protein levels in the cardiac tissue from mice 3 days post-MI (n = 3). The data are presented as mean ± SEM. The statistical significance of the data was evaluated using a Student’s two-tailed t test (H), and two-way ANOVA followed by Tukey’s test for multiple comparisons (B, D, E, G, I, J, K, L, and N). *P < 0.05; **P < 0.01.

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