Fig. 1: Ferroptosis was induced in ulcerative colitis.
From: HIF-1α alleviates ferroptosis in ulcerative colitis by regulation of GPX4
A Representative H&E staining images of colon tissues from normal controls (NC) and UC patients (Scale: 100 μm). B Detection of MDA levels in human intestinal tissues using MDA assay kit. C Iron levels of colonic biopsy tissue were determined by iron assay kit. D–F The protein and mRNA expression levels of FTH and FTL in colon tissues assessed by Western blot and RT-qPCR. G Transmission electron micrographs of colon epithelial cells from UC and NC samples (Scale: 1 μm, 0.5 μm). Blue arrows indicate mitochondrial atrophy. H–L Immunohistochemical staining of SLC7A11, GPX4, TXNRD1, ACSL4, LPCAT3 in UC and NC samples (Scale: 100 μm, 50 μm). ****P < 0.0001.
