Fig. 2: PML-NBs increased with cell cycle arrest during interphase in HL60 cells. | Cell Death & Disease

Fig. 2: PML-NBs increased with cell cycle arrest during interphase in HL60 cells.

From: Enlarged PML-nuclear bodies trigger conflicting cell cycle signal-mediated cytotoxicity in leukemia cells

Fig. 2

a Cell cycle status was assessed 24 h post-treatment with CDK4/6i, CDK1i, or serum-free medium, as well as at the indicated time points following incubation in drug-free medium after a 24 h prior treatment with CDK1i. Representative data from three independent experiments are shown. b, c Immunofluorescent staining for PML-NBs was performed at the time points indicated in (a). Representative images and the mean + SD of the number of PML-NBs per nucleus are shown in d (n = 4). **P < 0.01; *P < 0.05 (Tukey–Kramer’s test).

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