Fig. 1: Aberrantly activated expression of TRIM31 and its negative association with prognostic outcome in CRC. | Cell Death & Disease

Fig. 1: Aberrantly activated expression of TRIM31 and its negative association with prognostic outcome in CRC.

From: TRIM31 triggers colorectal carcinogenesis and progression by maintaining YBX1 protein stability through ubiquitination modification

Fig. 1: Aberrantly activated expression of TRIM31 and its negative association with prognostic outcome in CRC.

A The distribution of 85 tripartite motif containing (TRIM) gene family protein-coding genes among all chromosomes. B Heatmap analysis of differential expression patterns of the TRIM protein family in colorectal tumor tissue (orange) and adjacent normal tissue (blue) in two independent datasets (GSE134525 [left] and GSE103512 [right]). C Box plot depicting TRIM31 expression (log2 TPM values) across four tissue cohorts. D Activation of TRIM31 were associated with shorter OS in TCGA-COAD, and worse OS/DFS in Rectal_MSK2022 cohort. E Demonstration of TRIM31 immunohistochemical staining differences between normal colon tissue and three colorectal tumors (Tumor-1/2/3) at 10X/20X magnification.Scale bar, 100 µm. F The histogram showed that tumor tissue had significantly higher TRIM31 IHC scores than normal tissue, n = 24 per group. G Survival curves confirmed that patients in the TRIM31 high expression group (n = 57) had a lower overall survival rate than those in the low expression group (n = 19). TRIM31 expression in normal colorectal cells (NCM460) and colorectal cancer cells, assessed by qRT-PCR (H) and Western Blot (I), n = 3 per group. **P < 0.01; ***p < 0.001.

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