Fig. 5: C-Jun-mediated TNF-α/p-STAT1 activation induces MHC-I expression in ATM knockdown TNBC. | Cell Death & Disease

Fig. 5: C-Jun-mediated TNF-α/p-STAT1 activation induces MHC-I expression in ATM knockdown TNBC.

From: Inhibition of ATM enhances the immunogenicity of triple-negative breast cancer by promoting MHC-I expression

Fig. 5

A, B Protein expression by Western blot analyses of ATM, TNF-α, HLA, p-c-Jun and c-Jun in MDA-MB-231, HCC1937, SUM159 and BT549 cells with indicated treatments. Quantitative of relative TNF-α, p-c-Jun and HLA protein levels. C, E) Protein expression by Western blot analyses of TNF-α, p-STAT1, STAT1 and HLA in MDA-MB-231, HCC1937, SUM159 and BT549 cells with indicated treatments. Quantitative of relative p-STAT1 and HLA protein levels. D, F mRNA levels by qRT-PCR analyses of HLA-A in MDA-MB-231, HCC1937, SUM159 and BT549 cells with indicated treatments. Error bars represent mean ± SD. Two-tailed Student’s t test was used for statistical analysis. *P < 0.05; **P < 0.01; ns, not significant, P > 0.05.

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