Scheme 1 | Cell Death & Disease

Scheme 1

From: Pharmacological activation of SIRT6 suppresses progression of head and neck and esophageal squamous cell carcinoma by modulation of cellular metabolism and protein translation

Scheme 1The alternative text for this image may have been generated using AI.

Left panel: A steady state is characterized by low SIRT6 expression and active PI3K/AKT/mTOR signaling that promotes glycolysis, protein translation, cell growth and survival. Middle panel: MDL-800 activates SIRT6, leading to the inhibition of mTOR, consequently inhibiting glycolysis, protein translation and cell proliferation. MDL-800 activity is attenuated by an upstream feedback loop activating AKT via IGF-1R/IR. Right panel: Blocking PI3K using BYL719 sensitizes cells to MDL-800 treatment and shows superior and synergistic anti-tumor activity. Created in BioRender. Elkabets, M. (2025)/o1ku47s.

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