Fig. 4: Genetic Variant Classification and Distribution in ATs Associated with CRC.

A Classification of AT Variants: Bar graph displaying the distribution of genetic variants type, deletions (DEL), insertion-deletions (DELINS), inversions (INV), and single nucleotide variants (SNVs), identified in AT adjacent to CRC, including Intra-VAT, Peri-VAT, HVAT and SAT. Intra-VAT group shows the highest diversity, especially in SNVs. B Shared and Exclusive Variants in ATs: (Up) Venn diagram illustrating the overlap and exclusivity of genetic variants among the four AT types. Intra-VAT harbors the highest number of unique variants (n = 7), while HLA-B and TYRO3_2 represents the only variants shared across all tissue types; (Down) related panel detailing the specific shared and exclusive variants. C Key signaling pathways involving mutated genes in adipose cells within and surrounding CRC tissue: Schematic representation of key signaling pathways affected by genes mutated in adipose cells located within or adjacent to CRC tissues. These pathways are implicated in cancer-related processes such as cell proliferation, immune evasion, and angiogenesis. (n = 3 per group). Panel C was created using BioRender (https://biorender.com/).