Fig. 5: Genomic landscape of CRC variants. | Cell Death & Disease

Fig. 5: Genomic landscape of CRC variants.

From: Adipose-tumor crosstalk in colorectal cancer: Identifying (Epi)genetic biomarkers for tumor progression and cachexia

Fig. 5

A Top 10 Mutated Genes in CRC: Bar graph showing the top 10 most frequently mutated genes in CRC, with APC (76%), TP53 (55%), and KRAS (42%) as the most common. B Pathways involvement of frequently mutated genes: Schematic illustration of the top 10 most frequently mutated CRC genes (shown in red) and their involvement in key signaling pathways. C Biological Impact of CRC Variants: Pie chart illustrating the functional classification of detected variants in CRC tissues. Variants of uncertain significance (VUS) represented the majority (74%), while pathogenic and likely pathogenic variants accounted for 1% and 25%, respectively. D Distribution of Variant Type in CRC Tissue: Pie chart showing the relative proportion of mutation types. Single nucleotide variants (SNVs) were the most prevalent (53.8%), followed by stop codon mutations (41.8%) and a minor fraction of insertion/deletion events (2.2%). Panel B was created using BioRender (https://biorender.com/).

Back to article page