Fig. 6: Molecular pathways mediated by shared mutations in CRC and AT cells. | Cell Death & Disease

Fig. 6: Molecular pathways mediated by shared mutations in CRC and AT cells.

From: Adipose-tumor crosstalk in colorectal cancer: Identifying (Epi)genetic biomarkers for tumor progression and cachexia

Fig. 6

Schematic representation of the tumor microenvironment (TME) illustrating the molecular interplay between CRC cells and surrounding AT compartments, including Intra-VAT, Peri-VAT, HVAT, and SAT. Shared mutations in genes are implicated in the activation of key oncogenic processes, including tumor progression, immune evasion, resistance to apoptosis, and therapy resistance. This model highlights potential crosstalk mechanisms between CRC and AT. This figure was created using BioRender (https://biorender.com/).

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