Fig. 5: Repeated oligodendrocyte ablations resulted in axonal injury. | Cell Death & Disease

Fig. 5: Repeated oligodendrocyte ablations resulted in axonal injury.

From: Repeated ablations of mature Tmem10+ oligodendrocytes recapitulates key pathological features of multiple sclerosis with prolonged demyelination

Fig. 5: Repeated oligodendrocyte ablations resulted in axonal injury.The alternative text for this image may have been generated using AI.

A, B SMI32 immunostaining and quantification suggested the intensity of SMI32 in the corpus callosum of DTR/DT mice was significantly increased compared with control/DT mice at 4 weeks after the 3rd round of DT injection. (n = 3 mice per group, scale bar = 200 μm, mean ± SEM, *p < 0.05, two-tailed t test). C, D SMI32 immunostaining and quantification indicated the intensity of SMI32 in the corpus callosum of DTR/DT mice was comparable to normal control level at 20 weeks after the 3rd round of DT injection. (n = 3-4 mice per group, scale bar = 200μm, mean ± SEM, ns not significant, two-tailed t test).

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