Fig. 2: The potential role of senescent macrophages on tumors.
From: Senescent macrophages in tumor: phenotypes, roles, and interventions
(1) Senescent macrophages suppress T cell proliferation through the downregulation of MHC II expression and the upregulation of PD-1 expression. (2) Senescent macrophages promote epithelial-mesenchymal transition (EMT) by increasing SPP1 expression, thereby facilitating tumor growth and angiogenesis. (3) Senescent macrophages’ secretion of senescence-associated secretory phenotype (SASP) factors drives tumor metastasis. (4) Senescent macrophages promote tumorigenesis and progression by upregulating CD22 expression, reducing phagocytic capacity, and inducing chronic inflammation through SASP secretion.
