Fig. 3: Senolytics and senomorphics eliminate senescent cells or suppress the SASP via multiple mechanisms. | Cell Death & Disease

Fig. 3: Senolytics and senomorphics eliminate senescent cells or suppress the SASP via multiple mechanisms.

From: Senescent macrophages in tumor: phenotypes, roles, and interventions

Fig. 3

D + Q, a tyrosine kinase inhibitor, induces apoptosis in senescent cells; Navitoclax and Fisetin promote apoptosis primarily through inhibition of Bcl-2 family proteins; FOXO4-DRI binds to FOXO4, disrupting its interaction with p53 to induce cell death; Niacin facilitates clearance by enhancing phagocytic activity; Rapamycin, Aspirin, and Metformin suppress SASP release by inhibiting NF-κB-related signaling pathways.

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