Fig. 3: OTUB1 impedes the gemcitabine response to PC cells in vivo. | Cell Death & Disease

Fig. 3: OTUB1 impedes the gemcitabine response to PC cells in vivo.

From: The deubiquitylase OTUB1 drives gemcitabine resistance in pancreatic cancer by enhancing pyrimidine metabolism through modulating DHODH mRNA stability

Fig. 3

A Schematic diagram of the generation and treatment of PC in CDXs. B, C Images of the tumor tissues (left) and the tumor growth curve (right) of the shOTUB1 group compared to the control (shNC group), with or without gemcitabine treatment. n = 6, *p < 0.05, **p < 0.01. D, E Comparison of tumor weights of the shOTUB1 group compared to the control (shNC group), with or without gemcitabine treatment. n = 6, *p < 0.05, **p < 0.01. F, G Kaplan–Meier analysis of OTUB1 deficiency CDXs treated with or without gemcitabine treatment. n = 6-10, *p < 0.05. H Representative images of Clevead-caspase-3 and Ki-67 staining of the tumor tissues from the indicated CDXs. Scale bar, 50 μm. I, J Quantification results of Clevead-caspase-3 and Ki-67 in the indicated groups. n = 6, *p < 0.05, **p < 0.01.

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