Fig. 9: Diagram depicts that targeting OTUB1 sensitizes pancreatic cancer to gemcitabine chemotherapy. | Cell Death & Disease

Fig. 9: Diagram depicts that targeting OTUB1 sensitizes pancreatic cancer to gemcitabine chemotherapy.

From: The deubiquitylase OTUB1 drives gemcitabine resistance in pancreatic cancer by enhancing pyrimidine metabolism through modulating DHODH mRNA stability

Fig. 9

OTUB1 interacts and stabilizes DDX3X to enhance DHODH-mediated de novo pyrimidine synthesis, thereby upregulating dCDP and dCTP for efficient DNA replication, reducing gemcitabine-induced replication stress, and conferring gemcitabine resistance in PC.

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