Fig. 1: Male mice lacking CHCHD2 exhibit motor defects with age. | Cell Death & Disease

Fig. 1: Male mice lacking CHCHD2 exhibit motor defects with age.

From: The CHCHD2-CHCHD10 protein complex is modulated by mitochondrial dysfunction and alters lipid homeostasis in the mouse brain

Fig. 1: Male mice lacking CHCHD2 exhibit motor defects with age.

A Body weight (BW) of male Chchd2 knockout (Chchd2–/–) and control (Chchd2+/+) mice at 6, 9 and 12 months; n > 15 per genotype and time point. B BW, quadriceps weight (QW) and heart weight (HW) measured in males at 12 months of age. Data are represented as means ± SEM; n > 20 per genotype; *p < 0.05, ns not significant. C Motor coordination measured as latency to fall (in s) from the rod in male mice from 6 to 12 months. D Muscular strength (in g) measured by grip strength test in male mice from 6 to 12 months. Data are represented as means ± SEM *p < 0.05; n > 18 per genotype. ns not significant. E, F CatWalk gait analysis performed in males at 12 months of age. Representative digitized paw prints are shown in with RF, right front paw, RH, right hind paw, LF, left front paw, and LH, left hind paw. Duration (in s), average speed (cm/s) and cadence (steps/s) to cross the walkway in each step cycle). Data are presented as mean ± SEM. n ≥ 4 *p < 0.05.

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