Fig. 4: Male mice lacking CHCHD2 exhibit regional alterations in lipid content in the brain. | Cell Death & Disease

Fig. 4: Male mice lacking CHCHD2 exhibit regional alterations in lipid content in the brain.

From: The CHCHD2-CHCHD10 protein complex is modulated by mitochondrial dysfunction and alters lipid homeostasis in the mouse brain

Fig. 4: Male mice lacking CHCHD2 exhibit regional alterations in lipid content in the brain.

A Volcano plots showing log₂(fold changes) and −log₁₀(p-values) of all detected m/z values in the cortex, dorsal striatum, and ventral striatum of Chchd2–/– (n = 7) and Chchd2+/+ (n = 9) male mice at 12 months of age. Each brain region was analyzed independently. Peak intensities were normalized, log₂-transformed, and assessed using multiple t-tests. Identified regulated lipids are highlighted with the monoisotopic peaks of their corresponding ions, indicated by red dashed lines. B Representative ion images of SHexCers (sulfohexosylceramides), HexCers (hexosylceramides), SMs (sphingomyelins), and PCs (Phosphatidylcholines) peaks in the cortex, dorsal and ventral striatum of Chchd2–/–and Chchd2+/+ male mice at the age of 12 months. The lateral resolution of the MALDI-FITCR-MS ion images is 100 µm, and all ion images were RMS-normalized.

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