Fig. 8: Altered expression of lipogenic and Ketogenic enzymes in fasted mice lacking C3G in hepatocytes. | Cell Death & Disease

Fig. 8: Altered expression of lipogenic and Ketogenic enzymes in fasted mice lacking C3G in hepatocytes.

From: Deletion of C3G in hepatocytes impairs full liver maturation and alters glucose homeostasis

Fig. 8

A RT-qPCR analysis of Acaca, Fasn, and Hmgcs2 mRNA expression in the liver of 1-month-old C3GKOAlb and wt mice after fasting for 4 and 48 h. B Western blot analysis of FAS, P-ACC, ACC, and CPT1A protein levels in livers from C3GKOAlb and wt mice after fasting for 4 and 48 h normalized with β-Actin. Histograms show the quantification of different western blots. C The graphic shows serum levels of beta-hydroxy-butyrate in 1-month-old C3GKOAlb and wt mice at different fasting times (4, 16, and 48 h). *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 compared to wt mice (n = 4–8).

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