Fig. 3: Engagement of glycolysis is necessary for NK cell migration. | Cell Death & Disease

Fig. 3: Engagement of glycolysis is necessary for NK cell migration.

From: Impaired natural killer cell migration in HIV-infected individuals is caused by TIGIT-mediated inhibition of HIF-1α-dependent glycolysis

Fig. 3

A CXCL12-triggered migration of NK cells in either glucose-containing or glucose-depleted medium (n = 9). B CXCL12-triggered migration of NK cells treated with different doses of 2-DG (0.5, 1, 2, and 5 mM) or DMSO (n = 3). C CXCL12-triggered migration of NK cells treated with 2-DG (2 mM) or DMSO (n = 6). A, C *P < 0.05 and **P < 0.01 (Wilcoxon matched-pairs signed rank test). D A representative flow cytometry plot demonstrating the effects of 2-DG (2 mM) or DMSO on the levels of F-Actin in CXCL12-stimulated NK cells. E The MFI of F-Actin in CXCL12-stimulated NK cells treated with 2-DG (2 mM) or DMSO (n = 9). *P < 0.05 and **P < 0.01 (Friedman test).

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