Fig. 1: Decreased nigrostriatal IDE levels and elevated serum IDE levels in A53T α-syn mice. | Cell Death & Disease

Fig. 1: Decreased nigrostriatal IDE levels and elevated serum IDE levels in A53T α-syn mice.

From: Insulin-degrading enzyme confers neuroprotection in Parkinson’s disease by inhibiting the Hippo signaling pathway

Fig. 1

A–C IDE protein levels were measured in SN and STR of 6, 12, 16-month-old A53T α-syn mice (n = 6) and WT control mice (n = 6). Quantified results of the expression of IDE were also displayed. **P < 0.01, ns not significant; Student’s t test. D Quantitative transcription analyses exhibiting the expression levels of IDE mRNA in 6, 12, 16-month-old A53T α-syn mice (n = 6) and WT control mice (n = 6). ****P < 0.0001, ns not significant; Student’s t test. E The total fasting serum IDE levels of 6, 12, 16-month-old A53T α-syn mice (n = 8-10) and WT control mice (n = 8–10) were measured in ELISA kits. ****P < 0.0001, *P < 0.05, ns not significant; Student’s t test.

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