Fig. 6: Proteome and transcriptome analyses revealing the Hippo signaling pathway mediating the neuroprotective effects of IDE. | Cell Death & Disease

Fig. 6: Proteome and transcriptome analyses revealing the Hippo signaling pathway mediating the neuroprotective effects of IDE.

From: Insulin-degrading enzyme confers neuroprotection in Parkinson’s disease by inhibiting the Hippo signaling pathway

Fig. 6

Comparative statistical histogram of DEGs in the SN (A) and STR (B) of each group of mice (n = 3 each group). Quantitative results of DEPs in the SN (C) and STR (D) of each group of mice (n = 3 per group). The volcano plots between A53T + IDE/A53T + Vector groups revealed the up (red) or downregulated (blue) DEGs in SN (E) and STR (F) in mice (n = 3 per group). Volcano plot of DEPs associated with the SN (G) and STR (H) in A53T + IDE/A53T + Vector groups, with significant upregulations as red dots and significant downregulations as blue dots (n = 3 per group). Considering all DEGs and DEPs in A53T + IDE/A53T + Vector groups, Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses identified the top 10 pathways in the transcriptome in SN (I), along with the proteomics in STR (J), respectively (n = 3 per group).

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