Fig. 2: Desmin deficiency leads to defects in cardiac development and embryonic body size. | Cell Death & Disease

Fig. 2: Desmin deficiency leads to defects in cardiac development and embryonic body size.

From: Molecular insights into the role of desmin intermediate filament network in chromatin landscape, cardiomyocyte differentiation, and maturation

Fig. 2

A Stereoscopic analysis of Des+/+ and Des−/− hearts at embryonic day E12.5 (Ai: n = 7 Des+/+ and n = 8 Des−/−) and E14.5 (Aii: n = 7 Des+/+ and Des−/−). B Histological analysis of hematoxylin & eosin-stained representative paraffin sections of E12.5 (Bi: n = 3 Des+/+ and Des−/−) and E14.5 hearts (Bii: n = 4 Des+/+and Des−/−) of Des+/+and Des−/− embryos. RV: right ventricle, LV: left ventricle. C Quantitation of cardiac trabeculae and cardiac wall thickness of the left ventricle of E14.5 embryonic hearts. (n = 11 Des+/+and Des−/−). D Stereoscopic analysis of Des+/+ and Des−/− whole body at embryonic day Di) E12.5 (n = 7 Des+/+ and n = 6 Des−/−) and Dii) E14.5 (n = 7 Des+/+and Des−/−). E Quantitation of body width and height (measured in millimeters) at embryonic day E12.5 (Ei) and E14.5 (Eii) (right panels). Statistical analysis by unpaired Student’s t-test. All data are presented as means ± SEM. *p < 0.005 of Des+/+ vs. Des−/−.

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