Fig. 3: Desmin is expressed in the Pdgfra+/Gfra2+/Kdr+ CPC population and regulates its size. | Cell Death & Disease

Fig. 3: Desmin is expressed in the Pdgfra+/Gfra2+/Kdr+ CPC population and regulates its size.

From: Molecular insights into the role of desmin intermediate filament network in chromatin landscape, cardiomyocyte differentiation, and maturation

Fig. 3

A FACS analyses of desmin expression in Pdgfra+/Gfra2+/Kdr+ CPCs isolated from mouse hearts at embryonic days E7.5 (n = 2), E8.5 (n = 3), E9.5 (n = 3) and E10.5 (n = 2). The first plot presents the cardiac cell population according to Pdgfra+/Gfra2+ expression. The second plot shows the percentage of Kdr+ cells in the Pdgfra+/Gfra2+ population, and the third plot shows the percentage of Pdgfra+/Gfra2+/Kdr+ population that expresses desmin. B FACS plots of CPCs isolated from Des+/+ (Bi and Bii) vs. Des−/− (Biii and Biv) mouse hearts at E8.5, n = 2. The first plot presents the cardiac cell population according to Pdgfra+/Gfra2+ expression. The second plot shows the percentage of Kdr+ cells in the Pdgfra+/Gfra2+ population, that is, the triple-positive Pdgfra+/Gfra2+/Kdr+ CPCs. C FACS plots showing the percentage of MHC (Myh6) in the total cardiac cell population of Des+/+ (Ci) and Des−/− (Cii) of E8.5 mouse embryonic hearts. D Percentage of desmin+ cells in total cardiac cell population; the line with circles represents the percentage of cardiac cells that express desmin during E7.5-E10.5, the line with squares represents the percentage of CPCs that express desmin. CPCs cardiac progenitor cells.

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