Fig. 6: Desmin deficiency results in large-scale changes in gene expression. | Cell Death & Disease

Fig. 6: Desmin deficiency results in large-scale changes in gene expression.

From: Molecular insights into the role of desmin intermediate filament network in chromatin landscape, cardiomyocyte differentiation, and maturation

Fig. 6

A Volcano plot displaying differentially expressed genes as identified by RNA sequencing performed in adult cardiomyocytes (ACM) isolated from Des+/+ and Des−/− 3-month-old mice under basal and swimming stress conditions. Significantly different genes were considered with a log2FC cutoff of ≥ |0.6 | , p-value ≤ 0.05 and counts ≥20 (B) GO annotation analysis showed a significantly altered group of genes in the absence of desmin. C Heatmaps showing expression change of representative genes important for cardiogenicity and also identified in the RNA seq performed on D7 iCMs (Fig. 1). ACM adult cardiomyocytes, p-adjust: adjusted p-value = negative log of 10, counts: number of genes in each category.

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