Table 2 Top decile of upregulated transcripts ranked by Manhattan Distance of combined Fold change and significance in iNPCBD versus iNPCWT.

From: CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival

Name

Fold change (log2)

Significance (p-value -Log10)

Manhattan distance

CHCHD2

11.06591415

49.10691918

60.17283332

TRBC2

9.924470423

25.85531867

35.77978909

CLU

3.643511368

26.37182294

30.0153343

EFEMP1

9.263777885

17.00989933

26.27367722

IGFBP3

4.134412383

20.42169324

24.55610562

CST1

7.169891738

16.05969888

23.22959062

GLRX

2.788128757

17.04304772

19.83117648

CRABP1

5.335897544

14.09487304

19.43077059

KRT19

2.359020279

16.62265506

18.98167534

TOX2

8.547148209

10.16845509

18.7156033

PENK

8.490096037

10.08345696

18.57355299

SBF2

4.890817753

13.29397505

18.18479281

SOCS2

7.712830571

6.200982101

13.91381267

SOX15

7.705149255

5.942586671

13.64773593

C1R

7.555636499

5.718129121

13.27376562

MGP

1.687985984

11.43220357

13.12018955