Fig. 5: USP7 modulated metabolic reprogramming of the M1 macrophages.

A, B ECAR and OCR analysis from the results of Seahorse assay, respectively. C–E The results of glucose consumption, lactate production, LDH activity based on biochemical kits. F GLUT1, HK-2, PKM2 and LDHA protein expression from the results of Western blot. n = 3. *p < 0.05, **p < 0.01, ***p < 0.001.