Fig. 6: USP7 mediated PKM2 deubiquitination and altered its phosphorylation and nuclear translocation. | Cell Death & Disease

Fig. 6: USP7 mediated PKM2 deubiquitination and altered its phosphorylation and nuclear translocation.

From: Ubiquitin-specific protease 7 regulates macrophage polarization via pyruvate kinase M2-mediated metabolic reprogramming in severe acute pancreatitis

Fig. 6

A The interaction between USP7 and PKM2 was identified based on the Co-IP results. B Ubiquitination level of PKM2 protein based on the results from the immunoprecipitation and ubiquitinated antibody detection. C PKM2 and p-PKM2 protein levels from the results of Western blot. D PKM2 protein expression in the cell nucleus and cytoplasm from the results of Western blot. n = 3. *p < 0.05, **p < 0.01.

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