Table 1 Top 10 hits from the CRISPR-Cas9 screen using MAGeCK robust ranking aggregation (RRA)-scores of sgRNAs in OMM1.3 cells at D35 compared to D0.
id | num | neg|score | neg|p-value | neg|fdr | neg|rank | neg|goodsgrna | neg|lfc | pos|score | pos|p-value | pos|fdr | pos|rank | pos|goodsgrna | pos|lfc |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DAXX | 4 | 0.00023702 | 0.0010823 | 0.152602 | 1 | 3 | −0.93234 | 0.12217 | 0.20515 | 0.923331 | 26 | 1 | −0.93234 |
SETDB1 | 4 | 0.013236 | 0.035616 | 0.782619 | 2 | 2 | −0.39488 | 0.71051 | 0.70898 | 0.974234 | 100 | 0 | −0.39488 |
KDM5C | 4 | 0.014218 | 0.03783 | 0.782619 | 3 | 2 | −0.18554 | 0.13538 | 0.22226 | 0.923331 | 30 | 1 | −0.18554 |
PRMT6 | 4 | 0.01819 | 0.046837 | 0.782619 | 4 | 2 | −0.37276 | 0.69276 | 0.6914 | 0.974234 | 99 | 0 | −0.37276 |
CHD1L | 4 | 0.025396 | 0.063406 | 0.782619 | 5 | 1 | −0.53367 | 0.71908 | 0.71756 | 0.974234 | 102 | 0 | −0.53367 |
MLLT11 | 2 | 0.027284 | 0.04986 | 0.782619 | 6 | 1 | −0.38805 | 0.21259 | 0.22753 | 0.923331 | 44 | 1 | −0.38805 |
KDM4D | 4 | 0.029838 | 0.073351 | 0.782619 | 7 | 2 | −0.23637 | 0.46253 | 0.49102 | 0.958623 | 68 | 1 | −0.23637 |
PRDM14 | 4 | 0.030329 | 0.074418 | 0.782619 | 8 | 3 | −0.11042 | 0.29956 | 0.38445 | 0.958623 | 54 | 1 | −0.11042 |
HIRA | 4 | 0.032562 | 0.079555 | 0.782619 | 9 | 1 | −0.2559 | 0.65485 | 0.65356 | 0.964831 | 95 | 0 | −0.2559 |
SETD1B | 4 | 0.039688 | 0.094747 | 0.782619 | 10 | 2 | −0.1836 | 0.6482 | 0.64722 | 0.964831 | 93 | 1 | −0.1836 |
