Table 2 Common genes across the five SETDB1-KD cell lines that were significantly downregulated compared to control cells.

ENSG00000080822

CLDND1

Claudin domain containing 1

−2.44067942

2.58731E-54

ENSG00000176087

SLC35A4

Solute carrier family 35 member A4

−1.730216179

6.70621E-54

ENSG00000136261

BZW2

Basic leucine zipper and W2 domains 2

−1.53357307

1.77831E-33

ENSG00000143379

SETDB1

SET domain bifurcated histone lysine methyltransferase 1

−1.507300673

3.46712E-47

ENSG00000176720

BOK

BCL2 family apoptosis regulator BOK

−1.503384978

1.02184E-19

ENSG00000197415

VEPH1

Ventricular zone expressed PH domain containing 1

−1.440234166

0.011404577

ENSG00000126970

ZC4H2

Zinc finger C4H2-type containing

−1.402321242

3.63752E-05

ENSG00000108774

RAB5C

RAB5C, member RAS oncogene family

−1.288855293

1.31662E-23

ENSG00000135678

CPM

Carboxypeptidase M

−1.260576418

4.44947E-10

ENSG00000100191

SLC5A4

Solute carrier family 5 member 4

−1.259885791

0.014637052

ENSG00000101282

RSPO4

R-spondin 4

−1.24160913

0.021345207

ENSG00000236609

ZNF853

Zinc finger protein 853

−1.208217162

0.001938456

ENSG00000168061

SAC3D1

SAC3 domain containing 1

−1.163129084

1.60468E-12

ENSG00000112576

CCND3

Cyclin D3

−1.152456908

2.45482E-48

ENSG00000134779

TPGS2

Tubulin polyglutamylase complex subunit 2

−1.129447327

1.53548E-26

ENSG00000163870

TPRA1

Transmembrane protein adipocyte associated 1

−1.097353862

7.10679E-39

ENSG00000138111

MFSD13A

Major facilitator superfamily domain containing 13A

−1.081598123

7.26073E-13

ENSG00000198794

SCAMP5

Secretory carrier membrane protein 5

−1.069454475

1.43271E-14

ENSG00000141543

EIF4A3

Eukaryotic translation initiation factor 4A3

−1.053239423

5.13661E-21

ENSG00000102230

PCYT1B

Phosphate cytidylyltransferase 1B, choline

−1.046421228

4.22045E-08

ENSG00000135097

MSI1

Musashi RNA binding protein 1

−1.037804441

5.79642E-10

ENSG00000183624

HMCES

5-hydroxymethylcytosine binding, ES cell specific

−1.03418709

5.91112E-12

ENSG00000144043

TEX261

Testis expressed 261

−1.018612109

1.10457E-43

ENSG00000094804

CDC6

Cell division cycle 6

−1.014134633

1.72692E-25

ENSG00000197147

LRRC8B

Leucine rich repeat containing 8 VRAC subunit B

−0.998151811

4.25272E-13

ENSG00000102977

ACD

ACD shelterin complex subunit and telomerase recruitment factor

−0.990099933

6.25433E-18

ENSG00000275591

XKR5

XK related 5

−0.988185209

0.002695943

ENSG00000176454

LPCAT4

Lysophosphatidylcholine acyltransferase 4

−0.985862564

2.7143E-15

ENSG00000173653

RCE1

Ras converting CAAX endopeptidase 1

−0.984715649

7.9172E-26

ENSG00000007062

PROM1

Prominin 1

−0.97961611

0.009103299

ENSG00000104369

JPH1

Junctophilin 1

−0.977497844

8.80282E-09

ENSG00000180998

GPR137C

G protein-coupled receptor 137C

−0.974003522

0.00222764

ENSG00000178999

AURKB

Aurora kinase B

−0.966160873

4.06418E-33

ENSG00000103502

CDIPT

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

−0.951329558

3.04278E-22

ENSG00000196081

ZNF724

Zinc finger protein 724

−0.950308152

0.013396392

ENSG00000127220

ABHD8

Abhydrolase domain containing 8

−0.944454528

6.54254E-10

ENSG00000162517

PEF1

Penta-EF-hand domain containing 1

−0.939626338

1.33625E-15

ENSG00000172731

LRRC20

Leucine rich repeat containing 20

−0.935106976

1.72682E-11

ENSG00000088881

EBF4

EBF family member 4

−0.933391831

0.034477292

ENSG00000167700

MFSD3

Major facilitator superfamily domain containing 3

−0.928218276

1.883E-16

ENSG00000109079

TNFAIP1

TNF alpha induced protein 1

−0.916384936

4.07361E-23

ENSG00000183726

TMEM50A

Transmembrane protein 50A

−0.909466682

2.40125E-14

ENSG00000093009

CDC45

Cell division cycle 45

−0.907262883

4.28719E-19

ENSG00000233927

RPS28

Ribosomal protein S28

−0.897534175

8.88364E-14

ENSG00000007968

E2F2

E2F transcription factor 2

−0.89724828

2.11235E-14

ENSG00000163964

PIGX

Phosphatidylinositol glycan anchor biosynthesis class X

−0.893049786

6.33205E-11

ENSG00000197696

NMB

Neuromedin B

−0.881664148

0.000489433

ENSG00000160767

FAM189B

Family with sequence similarity 189 member B

−0.878099585

3.43974E-32

ENSG00000128408

RIBC2

RIB43A domain with coiled-coils 2

−0.876289923

2.7777E-05

ENSG00000131873

CHSY1

Chondroitin sulfate synthase 1

−0.876260038

3.45611E-27

ENSG00000130830

MPP1

Membrane palmitoylated protein 1

−0.863737396

1.43029E-11

ENSG00000128604

IRF5

Interferon regulatory factor 5

−0.859313035

0.027699243

ENSG00000065328

MCM10

Minichromosome maintenance 10 replication initiation factor

−0.85800114

8.95999E-16

ENSG00000100139

MICALL1

MICAL like 1

−0.850088943

3.82816E-22

ENSG00000146094

DOK3

Docking protein 3

−0.849727315

0.01351518

ENSG00000099617

EFNA2

Ephrin A2

−0.84965942

0.000183769

ENSG00000008118

CAMK1G

Calcium/calmodulin dependent protein kinase IG

−0.839801505

8.3045E-06

ENSG00000109084

TMEM97

Transmembrane protein 97

−0.835177517

3.98655E-15

ENSG00000104524

PYCR3

Pyrroline-5-carboxylate reductase 3

−0.833707143

3.48264E-17

ENSG00000181991

MRPS11

Mitochondrial ribosomal protein S11

−0.828776036

1.70901E-20

ENSG00000197312

DDI2

DNA damage inducible 1 homolog 2

−0.821175254

1.12384E-11

ENSG00000131504

DIAPH1

Diaphanous related formin 1

−0.818668953

3.61781E-30

ENSG00000141401

IMPA2

Inositol monophosphatase 2

−0.8179472

3.21857E-09

ENSG00000007541

PIGQ

Phosphatidylinositol glycan anchor biosynthesis class Q

−0.815324807

3.82816E-22

ENSG00000039068

CDH1

Cadherin 1

−0.813795041

0.007133781

ENSG00000136052

SLC41A2

Solute carrier family 41 member 2

−0.809068678

0.000110523

ENSG00000006625

GGCT

Gamma-glutamylcyclotransferase

−0.808252948

7.97127E-08

ENSG00000159259

CHAF1B

Chromatin assembly factor 1 subunit B

−0.803311835

4.58958E-17

ENSG00000135622

SEMA4F

Semaphorin 4F

−0.79905126

3.1063E-11

ENSG00000003989

SLC7A2

Solute carrier family 7 member 2

−0.798981174

1.70805E-06

ENSG00000111199

TRPV4

Transient receptor potential cation channel subfamily V member 4

−0.795894675

0.026723176

ENSG00000111666

CHPT1

Choline phosphotransferase 1

−0.790075556

8.37199E-07

ENSG00000132563

REEP2

Receptor accessory protein 2

−0.789760272

0.017578955

ENSG00000166803

PCLAF

PCNA clamp associated factor

−0.787731791

2.9663E-10

ENSG00000103018

CYB5B

Cytochrome b5 type B

−0.782156755

6.96841E-07

ENSG00000205309

NT5M

5′,3′-nucleotidase, mitochondrial

−0.779227105

0.015346667

ENSG00000163888

CAMK2N2

Calcium/calmodulin dependent protein kinase II inhibitor 2

−0.777929574

0.004548607

ENSG00000167272

POP5

POP5 homolog, ribonuclease P/MRP subunit

−0.776677827

8.58558E-11

ENSG00000112039

FANCE

FA complementation group E

−0.776465629

1.15064E-10

ENSG00000165046

LETM2

Leucine zipper and EF-hand containing transmembrane protein 2

−0.775536248

0.00139097

ENSG00000254087

LYN

LYN proto-oncogene, Src family tyrosine kinase

−0.775426645

2.03074E-15

ENSG00000267534

S1PR2

Sphingosine-1-phosphate receptor 2

−0.773810704

4.2899E-09

ENSG00000146670

CDCA5

Cell division cycle associated 5

−0.773646868

3.06923E-17

ENSG00000137404

NRM

Nurim

−0.772726067

8.13588E-20

ENSG00000116791

CRYZ

Crystallin zeta

−0.772545614

0.000174379

ENSG00000102384

CENPI

Centromere protein I

−0.769337411

2.02709E-10

ENSG00000152270

PDE3B

Phosphodiesterase 3B

−0.764313087

4.05836E-07

ENSG00000089063

TMEM230

Transmembrane protein 230

−0.760695783

4.69492E-08

ENSG00000187123

LYPD6

LY6/PLAUR domain containing 6

−0.760114435

3.36599E-09

ENSG00000117408

IPO13

Importin 13

−0.759202881

3.22313E-19

ENSG00000124587

PEX6

Peroxisomal biogenesis factor 6

−0.758743154

2.95953E-09

ENSG00000140365

COMMD4

COMM domain containing 4

−0.752311848

9.66051E-19

ENSG00000144935

TRPC1

Transient receptor potential cation channel subfamily C member 1

−0.749164557

0.011475086

ENSG00000125319

HROB

Homologous recombination factor with OB-fold

−0.747598102

7.23784E-12

ENSG00000170515

PA2G4

Proliferation-associated 2G4

−0.747546163

8.61016E-16

ENSG00000107796

ACTA2

Actin alpha 2, smooth muscle

−0.742851497

1.12389E-05

ENSG00000075218

GTSE1

G2 and S-phase expressed 1

−0.741904138

8.50653E-14

ENSG00000169105

CHST14

Carbohydrate sulfotransferase 14

−0.740579126

6.41331E-17

ENSG00000276043

UHRF1

Ubiquitin like with PHD and ring finger domains 1

−0.736980602

4.32998E-10

ENSG00000167005

NUDT21

Nudix hydrolase 21

−0.735118324

6.40005E-08

ENSG00000165806

CASP7

Caspase 7

−0.733408293

1.08616E-07

ENSG00000159147

DONSON

DNA replication fork stabilization factor DONSON

−0.733330798

1.79372E-08

ENSG00000137310

TCF19

Transcription factor 19

−0.73287457

2.6109E-11

ENSG00000188186

LAMTOR4

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4

−0.731023031

3.67345E-05

ENSG00000189057

FAM111B

FAM111 trypsin like peptidase B

−0.729814217

3.26705E-06

ENSG00000113119

TMCO6

Transmembrane and coiled-coil domains 6

−0.729753081

3.77511E-08

ENSG00000132016

BRME1

Break repair meiotic recombinase recruitment factor 1

−0.729700409

0.001873868

ENSG00000160753

RUSC1

RUN and SH3 domain containing 1

−0.728484775

5.50404E-17

ENSG00000166508

MCM7

Minichromosome maintenance complex component 7

−0.728365624

2.96948E-16

ENSG00000221955

SLC12A8

Solute carrier family 12 member 8

−0.726823055

0.039726441

ENSG00000109519

GRPEL1

GrpE like 1, mitochondrial

−0.725689313

6.80513E-09

ENSG00000123685

BATF3

Basic leucine zipper ATF-like transcription factor 3

−0.72458263

0.001522053

ENSG00000148110

MFSD14B

Major facilitator superfamily domain containing 14B

−0.722394583

1.8746E-13

ENSG00000177917

ARL6IP6

ADP ribosylation factor like GTPase 6 interacting protein 6

−0.718700533

1.42364E-08

ENSG00000180228

PRKRA

Protein activator of interferon induced protein kinase EIF2AK2

−0.716677371

2.02939E-12

ENSG00000136574

GATA4

GATA binding protein 4

−0.711352562

0.007185606

ENSG00000077152

UBE2T

Ubiquitin conjugating enzyme E2 T

−0.709554446

1.08386E-14

ENSG00000183010

PYCR1

Pyrroline-5-carboxylate reductase 1

−0.708477376

3.11792E-10

ENSG00000146648

EGFR

Epidermal growth factor receptor

−0.70834571

0.001003247

ENSG00000085840

ORC1

Origin recognition complex subunit 1

−0.707703656

1.16587E-11

ENSG00000064393

HIPK2

Homeodomain interacting protein kinase 2

−0.706969488

1.76206E-14

ENSG00000141542

RAB40B

RAB40B, member RAS oncogene family

−0.703840844

0.001296392

ENSG00000143590

EFNA3

Ephrin A3

−0.703826254

0.004199258

ENSG00000105676

ARMC6

Armadillo repeat containing 6

−0.702557762

2.88567E-20

ENSG00000130734

ATG4D

Autophagy related 4D cysteine peptidase

−0.700560962

7.30284E-14

ENSG00000176974

SHMT1

Serine hydroxymethyltransferase 1

−0.700145922

2.87823E-09

ENSG00000168792

ABHD15

Abhydrolase domain containing 15

−0.699505212

7.30284E-14

ENSG00000163577

EIF5A2

Eukaryotic translation initiation factor 5A2

−0.698832403

5.90333E-07

ENSG00000149636

DSN1

DSN1 component of MIS12 kinetochore complex

−0.69800473

1.72175E-09

ENSG00000054277

OPN3

Opsin 3

−0.697429021

0.005367454

ENSG00000158109

TPRG1L

Tumor protein p63 regulated 1 like

−0.69576735

7.88947E-12

ENSG00000007255

TRAPPC6A

Trafficking protein particle complex subunit 6A

−0.69333341

0.003909706

ENSG00000186318

BACE1

Beta-secretase 1

−0.693003562

1.59805E-10

ENSG00000123444

KBTBD4

Kelch repeat and BTB domain containing 4

−0.691858123

1.14532E-08

ENSG00000129173

E2F8

E2F transcription factor 8

−0.691368268

1.53483E-07

ENSG00000116337

AMPD2

Adenosine monophosphate deaminase 2

−0.688901876

7.65844E-20

ENSG00000034152

MAP2K3

Mitogen-activated protein kinase kinase 3

−0.688418607

7.14337E-12

ENSG00000188312

CENPP

Centromere protein P

−0.687348522

1.41132E-07

ENSG00000101412

E2F1

E2F transcription factor 1

−0.685900049

1.57498E-11

ENSG00000178752

ERFE

Erythroferrone

−0.685630344

8.2682E-07

ENSG00000167513

CDT1

Chromatin licensing and DNA replication factor 1

−0.684859075

4.78247E-12

ENSG00000076248

UNG

Uracil DNA glycosylase

−0.684741771

9.43088E-09

ENSG00000143416

SELENBP1

Selenium binding protein 1

−0.684686569

3.17263E-08

ENSG00000144554

FANCD2

FA complementation group D2

−0.684496681

2.65731E-14

ENSG00000167524

RSKR

Ribosomal protein S6 kinase related

−0.684436037

0.040929878

ENSG00000170085

SIMC1

SUMO interacting motifs containing 1

−0.684107509

4.2041E-08

ENSG00000160233

LRRC3

Leucine rich repeat containing 3

−0.681849404

1.74181E-07

ENSG00000157927

RADIL

Rap associating with DIL domain

−0.67922331

2.07827E-05

ENSG00000136463

TACO1

Translational activator of cytochrome c oxidase I

−0.678764049

0.000179835

ENSG00000136146

MED4

Mediator complex subunit 4

−0.677778412

2.74481E-12

ENSG00000274641

H2BC17

H2B clustered histone 17

−0.676395464

1.28072E-07

ENSG00000140534

TICRR

TOPBP1 interacting checkpoint and replication regulator

−0.675488889

3.02285E-10

ENSG00000076003

MCM6

Minichromosome maintenance complex component 6

−0.675329486

1.48125E-10

ENSG00000187741

FANCA

FA complementation group A

−0.672648133

1.15152E-09

ENSG00000276368

H2AC14

H2A clustered histone 14

−0.672072742

2.72213E-06

ENSG00000106236

NPTX2

Neuronal pentraxin 2

−0.671365

0.034171406

ENSG00000111331

OAS3

2′-5′-oligoadenylate synthetase 3

−0.669574335

0.000154628

ENSG00000180011

ZADH2

Zinc binding alcohol dehydrogenase domain containing 2

−0.66559808

9.40295E-07

ENSG00000134987

WDR36

WD repeat domain 36

−0.664728619

3.40613E-09

ENSG00000116685

KIAA2013

KIAA2013

−0.66440737

1.57824E-10

ENSG00000131153

GINS2

GINS complex subunit 2

−0.663138222

3.08693E-10

ENSG00000165480

SKA3

Spindle and kinetochore associated complex subunit 3

−0.661381525

1.68765E-09

ENSG00000070366

SMG6

SMG6 nonsense mediated mRNA decay factor

−0.660870628

2.32961E-09

ENSG00000100401

RANGAP1

Ran GTPase activating protein 1

−0.660517742

6.83745E-16

ENSG00000169884

WNT10B

Wnt family member 10B

−0.657739715

7.54512E-06

ENSG00000004864

SLC25A13

Solute carrier family 25 member 13

−0.657514506

5.50404E-17

ENSG00000179532

DNHD1

Dynein heavy chain domain 1

−0.657360294

0.000903431

ENSG00000169679

BUB1

BUB1 mitotic checkpoint serine/threonine kinase

−0.65732404

1.12205E-15

ENSG00000092853

CLSPN

Claspin

−0.657027473

8.82631E-11

ENSG00000175175

PPM1E

Protein phosphatase, Mg2 + /Mn2+ dependent 1E

−0.656944979

0.009390568

ENSG00000128973

CLN6

CLN6 transmembrane ER protein

−0.656174514

1.45612E-13

ENSG00000132646

PCNA

Proliferating cell nuclear antigen

−0.654414489

2.43078E-10

ENSG00000136982

DSCC1

DNA replication and sister chromatid cohesion 1

−0.653987621

3.70426E-09

ENSG00000102387

TAF7L

TATA-box binding protein associated factor 7 like

−0.652644895

0.028474932

ENSG00000160957

RECQL4

RecQ like helicase 4

−0.652136684

2.0202E-12

ENSG00000160117

ANKLE1

Ankyrin repeat and LEM domain containing 1

−0.651964708

0.012275559

ENSG00000127564

PKMYT1

Protein kinase, membrane associated tyrosine/threonine 1

−0.650369204

1.59377E-11

ENSG00000116199

FAM20B

FAM20B glycosaminoglycan xylosylkinase

−0.650171171

2.25423E-05

ENSG00000148985

PGAP2

Post-GPI attachment to proteins 2

−0.650053227

4.6646E-10