Fig. 7: Effect of MET and MEK inhibitors on the transcriptional program induced by HGF and on the predicted regulatory network. | Cell Death & Disease

Fig. 7: Effect of MET and MEK inhibitors on the transcriptional program induced by HGF and on the predicted regulatory network.

From: Comprehensive map of the regulatory network triggered by MET exon 14 skipping reveals important involvement of the RAS-ERK signaling pathway

Fig. 7

A Heatmaps of differentially expressed genes (adj. p-value < 0.05 and absolute fold change > 1.5) in 16HBE METex14Del cells treated with capmatinib (CAPM) or trametinib (TRAM) and stimulated or not with HGF are shown (n = 4 per condition). B Zooms on the major regulatory node of the co-regulatory network of METex14Del cells in the presence and absence of inhibitors (CAPM, TRAM) upon stimulation with HGF. The radius of the circle is proportional to the number of target genes of the respective DIR. Co-regulatory interactions between transcription factors are indicated: protein-protein interactions with published evidence (blue line), transcriptional regulation interactions with published evidence (red arrow), and interactions defined only by the h-LICORN algorithm (gray line). C Expression of selected target genes regulated by ETS1, FOSL1, SMAD3 are shown in box-and-whisker plots. The box plot shows the 25th, 50th, and 75th percentiles, while the blue dots show the variant stabilization transformation (VST) of gene expression for each sample (n = 4 per condition). The median is indicated by the line across the box.

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