Table 2 KRAS and metabolism in TME.

Cancer type	Target	Metabolism type	Immune-related molecules	immune cells	Refs.
PDAC	UGCG	Glycosphingolipids	IFNγ /IFNGR1	NK and CD8 + T cells	[93]
Lung cancer	FASN	Phosphatidylcholines and triacylglycerides	—	—	[94]
PDAC	PPARδ	Lipid metabolism	CCL2/CCR2	Macrophages and MDSCs	[97]
CRC	GGPP	Cholesterol metabolism	IL-10	B cell	[98]
PDAC	CIB1	Glycolysis metabolism	PD-1	CD8 + T cells	[19]
PDAC	HK1/2 and LDHA	Lactate production	—	Macrophages	[105]
CRC	SLC25A22	Glutamate metabolism	CXCL1/CXCR2	MDSC	[109]
Lung cancer	SLC7A5	Glutamine metabolism	mTORC1	—	[111]

PDAC, pancreatic ductal adenocarcinoma, UGCG UDP-glucose ceramide glucosyltransferase, IFNγ interferon-gamma, IFNGR1 interferon gamma receptor 1, NK natural killer cell, FASN fatty acid synthase, PPARδ peroxisome proliferator-activated receptor delta, CCL2 C-C motif chemokine, CCR2 C-C motif receptor 2, MDSCs myeloid-derived suppressor cells, CRC colorectal cancer, GGPP geranylgeranyl pyrophosphate, IL-10 interleukin-10, CIB1 chorionic gonadotropin beta polypeptide 1, PD-1 programmed cell death protein 1, HK1/2 hexokinase 1/2, LDHA lactate dehydrogenase A, SLC25A22 mitochondrial glutamate carrier 1, CXCL1 C-X-C motif ligand 1, CXCR2 C-X-C motif chemokine receptor 2, SLC7A5 solute carrier family 7 member 5, mTORC1 mammalian target of rapamycin complex 1.

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