Fig. 7: Retinal histology and BLamD comparison of WT, R345W+/+, Casp1-/- R345W+/+, and Nlrp3-/- R345W+/+ 12 month mice. | Cell Death & Disease

Fig. 7: Retinal histology and BLamD comparison of WT, R345W+/+, Casp1-/- R345W+/+, and Nlrp3-/- R345W+/+ 12 month mice.

From: Genetic removal of Nlrp3 protects against age-related and R345W Efemp1-induced basal laminar deposit formation

Fig. 7: Retinal histology and BLamD comparison of WT, R345W+/+, Casp1-/- R345W+/+, and Nlrp3-/- R345W+/+ 12 month mice.The alt text for this image may have been generated using AI.

A H&E-stained retinal histology sections demonstrates that removal of Casp1 and Nlrp3 is well tolerated structurally. Scale bar = 100 µm. B Representative BLamD traced electron micrographs from each genotype. Scale bar = 2 µm. C Violin plot depicting comparative analysis of BLamD size per FOV across different genotypes. D Comparative analysis of the abundance of sub-FOVs containing BLamDs presented as percent coverage across BrM. n = 3 males/3 females for each genotype. Analysis performed using Kruskal-Wallis test. Note: TEM images of WT and R345W+/+ mice as well as quantification (C, D) are identical to the 12 month age group displayed earlier in Fig. 2.

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