Fig. 8: Muller cell gliosis is unaffected by the absence of Nlrp3 in R345W+/+ mice at 12 month. | Cell Death & Disease

Fig. 8: Muller cell gliosis is unaffected by the absence of Nlrp3 in R345W+/+ mice at 12 month.

From: Genetic removal of Nlrp3 protects against age-related and R345W Efemp1-induced basal laminar deposit formation

Fig. 8: Muller cell gliosis is unaffected by the absence of Nlrp3 in R345W+/+ mice at 12 month.The alt text for this image may have been generated using AI.

Representative images (n = 4) of retinal cross sections showing expression of Gfap (A, C, red) and Vim (B, D, green) along with nuclear stain DAPI (blue) as a reference (scale bar = 50 µm). Increased expression of Gfap and Vim is observed in Nlrp3−/− R345W+/+ mice (similar to that seen in R345W + /+ mice, cf. Fig. 5G, O) compared to Nlrp3−/− (or WT, cf. Fig. 5C, K) mice.

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