Fig. 1: Schematic diagram of epigenetic regulation mechanisms and drug resistance outcomes. | Cell Death & Disease

Fig. 1: Schematic diagram of epigenetic regulation mechanisms and drug resistance outcomes.

From: Resistance of first-line targeted drugs in hepatocellular carcinoma: the epigenetic regulation mechanisms

Fig. 1

The mechanisms of epigenetic regulation contributing to drug resistance include: DNA/RNA methylation, histone modifications, and non-coding RNA regulation; while the consequential manifestations of drug resistance encompass: escaped programmed cell death, tumor metabolic reprogramming, formation and maintenance of drug-resistant cells, uncontrolled cell proliferation signaling pathways and abnormal transport processes. Image created by Figdraw.

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