Fig. 6: Epigenetic modifications promote sorafenib resistance by facilitating the formation and maintenance of drug-resistant cells, involving the following regulators. | Cell Death & Disease

Fig. 6: Epigenetic modifications promote sorafenib resistance by facilitating the formation and maintenance of drug-resistant cells, involving the following regulators.

From: Resistance of first-line targeted drugs in hepatocellular carcinoma: the epigenetic regulation mechanisms

Fig. 6

a miR-3677-3p, miR-93, miR-361-3p, DNMT3a, DNMT3b, TET2, KDM5B, HDAC11, and METTL3 drive resistance by stimulating CSC expansion. b LINC01089, lncRNA H19, miR-125b-5p, LINC00540, circMEMO1, lncRNA DUXAP8, KIAA1429, and METTL3 drive resistance through EMT activation. Image created by Figdraw.

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