Fig. 8: Epigenetic modification promotes sorafenib resistance by regulating the HCC transport process, involving the following regulators. | Cell Death & Disease

Fig. 8: Epigenetic modification promotes sorafenib resistance by regulating the HCC transport process, involving the following regulators.

From: Resistance of first-line targeted drugs in hepatocellular carcinoma: the epigenetic regulation mechanisms

Fig. 8

a miR-138-1-3p promotes resistance by upregulating the drug efflux pump ABCB1. b METTL3 and METTL14 promote resistance by downregulating drug uptake transporters OATP1B1 and OATP1B3. c miR-4669, miR-1228, miR-494-3p, miR-93, and circUPF2 promote resistance via exosome-mediated transport. Image created by Figdraw.

Back to article page