Fig. 1: HAT1 is upregulated in LUAD and correlated with poor prognosis. | Cell Death & Disease

Fig. 1: HAT1 is upregulated in LUAD and correlated with poor prognosis.

From: HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma

Fig. 1

A Survival map analysis using the GEPIA database with a median cutoff. ACC (Adrenocortical carcinoma), BLCA (Bladder Urothelial Carcinoma), BRCA (Breast invasive carcinoma), CESC (Cervical squamous cell carcinoma and endocervical adenocarcinoma), CHOL(Cholangio carcinoma), COAD (Colon adenocarcinoma), DLBC (Lymphoid Neoplasm Diffuse Large B-cell Lymphoma), ESCA (Esophageal carcinoma), GBM (Glioblastoma multiforme), HNSC (Head and Neck squamous cell carcinoma), KICH (Kidney Chromophobe), KIRC (Kidney renal clear cell carcinoma), KIRP (Kidney renal papillary cell carcinoma), LAML (Acute Myeloid Leukemia), LGG(Brain Lower Grade Glioma), LIHC (Liver hepatocellular carcinoma), LUAD (Lung adenocarcinoma), LUSC (Lung squamous cell carcinoma), MESO (Mesothelioma), OV (Ovarian serous cystadenocarcinoma), PAAD (Pancreatic adenocarcinoma), PCPG (Pheochromocytoma and Paraganglioma), PRAD (Prostate adenocarcinoma), READ (Rectum adenocarcinoma), SARC (Sarcoma), SKCM (Skin Cutaneous Melanoma), STAD (Stomach adenocarcinoma), TGCT (Testicular Germ Cell Tumors), THCA (Thyroid carcinoma), THYM (Thymoma), UCEC (Uterine Corpus Endometrial Carcinoma), UCS (Uterine Carcinosarcoma), UVM (Uveal Melanoma). B Kaplan-Meier analysis of patients with high or low expression of HAT1 using the Tumor Lung Adenocarcinoma data set. C Kaplan-Meier analysis of patients with high or low expression of HAT1 using Mixed Lung Adenocarcinoma data set. D Analysis of the expression of HAT1 in LUAD GEPIA samples. E Analysis of the expression of HAT1 in LUAD CPTAC samples. F HAT1 IHC staining in normal tissues and in tumor tissues of different grades, including Grade Ⅰ, Grade Ⅱ, Grade Ⅲ and Grade Ⅳ (scale bar = 10 μm). G Analysis of the expression of HAT1 in normal tissues and in tumor tissues of different grades including Grade Ⅰ, Grade Ⅱ and Grade Ⅲ using LUAD CPTAC data set. H The expression of HAT1 in 14 pairs of normal and tumor tissues. (I) Relative protein expression of HAT1 in panel H. Data were analyzed using two-way analysis of variance (ANOVA), **P < 0.01.

Back to article page