Fig. 6: Lactylation of RPA1 on K88, K163, K167, and K267 sites promotes HR. | Cell Death & Disease

Fig. 6: Lactylation of RPA1 on K88, K163, K167, and K267 sites promotes HR.

From: HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma

Fig. 6: Lactylation of RPA1 on K88, K163, K167, and K267 sites promotes HR.

A The level of lactylated RPA1 in mutant cells with RPA1 K88R, K163R, K167R, and K267R. B The level of RPA1 interacting ssDNA in mutant cells with RPA1 K88R, K163R, K167R and K267R. C The level of RPA1 interacted with HR factors, including BLM, MRE11, RAD51, and NBS1, in mutant cells with RPA1 K88R, K163R, K167R, and K267R. D Relative HR efficiency in mutant cells with RPA1 K88R, K163R, K167R and K267R. All data were analyzed using two-way analysis of variance (ANOVA), **P < 0.01.

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