Fig. 8: HAT1-mediated lactylation promotes radiotherapy resistance in LUAD. | Cell Death & Disease

Fig. 8: HAT1-mediated lactylation promotes radiotherapy resistance in LUAD.

From: HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma

Fig. 8

A Photograph of tumors from indicated mice, including the control group, HAT1-KO group, and HAT1 inhibitor group with or without IR. B The tumor volume of the indicated mice, including the control group, the HAT1-KO group, and the HAT1 inhibitor group with or without IR. C The tumor weight of indicated mice, including the control group, HAT1-KO group, and HAT1 inhibitor group with or without IR. D H&E staining and IHC staining with Pan-Kla, HAT1, and Ki-67 in tumors from the control group, HAT1-KO group, and HAT1 inhibitor group with or without IR (scale bar = 30 μm). E The expression of global lactylated proteins, HAT1, and GAPDH in 14 pairs of normal tissues and tumor samples. F IHC staining with HAT1 and Pan-Kla on tissue microarray of consecutive sections (scale bar=20 μm). G The analysis of correlation between HAT1 and Pan-Kla according to intensity from panel E. H The analysis of correlation between HAT1 and Pan-Kla according to IHC score from F. All data were analyzed using two-way analysis of variance (ANOVA), *P < 0.05, **P < 0.01.

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