Fig. 6: HER3 and PHF8 expressions are positively correlated in TNBC specimens and the HER3/miR-34b-5p/PHF8 signaling axis significantly associates with survival outcomes in breast cancer patients. | Cell Death & Disease

Fig. 6: HER3 and PHF8 expressions are positively correlated in TNBC specimens and the HER3/miR-34b-5p/PHF8 signaling axis significantly associates with survival outcomes in breast cancer patients.

From: HER3 promotes triple-negative breast cancer progression by upregulating PHF8 via miR-34b-5p-dependent mechanism

Fig. 6: HER3 and PHF8 expressions are positively correlated in TNBC specimens and the HER3/miR-34b-5p/PHF8 signaling axis significantly associates with survival outcomes in breast cancer patients.

A Representative images of IHC staining for HER3 and PHF8 in TNBC specimens. A significantly positive correlation between HER3 and PHF8 was observed in TNBC specimens. B Kaplan-Meier survival curves showed that breast cancer patients with tumors expressing high mRNA levels of HER3 or PHF8 exhibited much worse overall survival than those patients with tumors expressing low mRNA levels of HER3 or PHF8, respectively. C The expression level of miR-34b-5p was significantly lower in TNBC tumors (orange, n = 254) than that in non-TNBC tumors (blue, n = 3777). Data was acquired from Breast Cancer Gene-Expression Miner v5.2 website. D Kaplan-Meier survival curves of overall survival of breast cancer patients from TCGA datasets. The log-rank tests were used to compare overall survival of breast cancer patients with tumors expressing high versus low expression levels of miR-34b-5p.

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