Fig. 7: Schematic model of the role of USP5 in regulating the YBX3/SLC7A11 to inhibit ferroptosis.

In the presence of USP5, USP5 promotes the translocation and aggregation of YBX3 in the lysosome, thereby mediating the degradation of YBX3 to prevent the degradation of SLC7A11 and inhibit ferroptosis in CRC.