Table 2 Cell death observed in respective cell line and docking score obtained from induced fit docking.
Compound | %Cell death | Docking score (kcal/mol) | |
|---|---|---|---|
Caco-2 | HT-29 | ||
Azelnidipine | 13.7 | 91.6 | −7.14 |
Bardoxolone methyl | 19.2 | 67.5 | −7.43 |
Cinacalcet | 49.4 | 70.3 | −4.75 |
Clomiphene | 34.7 | 52.0 | −5.21 |
Doramectin | 32.3 | 51.6 | −4.95 |
Dronedarone | 86.9 | 79.0 | −6.48 |
Efavirenz | 20.5 | 22.0 | −3.43 |
Embelin | 1.7 | 51.8 | −4.86 |
FTY720 | 67.9 | 69.1 | −6.06 |
Ivermectin | 5.2 | 78.9 | −4.98 |
Lomitapide | 81.7 | 72.9 | −7.48 |
Moxidectin | 8.4 | 78.4 | −3.82 |
Nebivolol | 45.0 | 67.3 | −6.66 |
Oxethazaine | 13.9 | 53.1 | −4.55 |
Penfluridol | 90.0 | 92.2 | −8.31 |
Pimozide | 59.9 | 64.6 | −6.5 |
Saikosaponin A | 1.2 | 87.6 | −6.56 |
Simeprevir | 5.5 | 70.9 | −4.57 |
Tamoxifen | 36.5 | 63.3 | −5.07 |
Terfenadine | 79.7 | 89.6 | −5.91 |
Vortioxetine | 52.1 | 52.1 | −5.31 |
VX-222 (VCH-222, Lomibuvir) | 36.3 | 78.5 | −5.9 |
