Fig. 1: CNOT7 is linked to radiation resistance and indicates a poor prognosis in CRC. | Cell Death & Disease

Fig. 1: CNOT7 is linked to radiation resistance and indicates a poor prognosis in CRC.

From: CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair

Fig. 1

A Schematic diagram of pre-treatment tissue proteome sequencing for CRC patients receiving neoadjuvant therapy. B Volcano diagram of differential proteins between CR group and SD group patients. C Volcano diagram of differential proteins between PR group and SD group patients. D The Venn diagram shows the common differential proteins between the CR/SD group and the PR/SD group. E Waterfall plot shows the changes in tumor burden of CRC patients undergoing radiotherapy from initiation to the best objective response. Patients were grouped based on the expression of CNOT7 in tumor tissue. Scale bar, 120 μm. F Table and histogram recapitulating the outcomes of 45 CRC patients who received radiotherapy. G Representative magnetic resonance (MR) images of the rectum showing tumor changes at baseline and the best response after radiotherapy. Red arrows indicate the lesions. The panels display the CNOT7 status and therapeutic evaluation. H Representative immunohistochemical images of CNOT7. Right scale bar, 100 μm. Left scale bar, 30 μm. I Western blotting of CNOT7 in CRC and adjacent normal tissues. J CNOT7 mRNA levels in CRC and adjacent normal tissues. K, L Kaplan-Meier curves were generated on the www.kmplot.com website to show the post-progression survival (K) and overall survival (L) in III and IV stage CRC patients with low or high CNOT7 expression.

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