Fig. 8: STL127705 enhances the anti-tumor effect of radiotherapy in CRC.

A Sensitivity curves for different doses of radiation treatment in HCT116 and CNOT7 knockdown HCT116 cells with or without STL127705 (30 µM) treatment. B Sensitivity curves for different doses of radiation treatment in SW480 and CNOT7 knockdown SW480 cells with or without STL127705 (30 µM) treatment. C Sensitivity curves for different concentrations of STL127705 in HCT116 and CNOT7 knockdown HCT116 cells with or without radiation. D Sensitivity curves for different concentrations of STL127705 in SW480 and CNOT7 knockdown SW480 cells with or without radiation. E Schematic diagram of construction and drug therapy for patient-derived tumor xenograft model. F Gross images of patient-derived tumor xenograft with or without radiotherapy and STL127705. G–I Tumor growth curves (G), tumor volume (H) and tumor weights (I) of patient-derived tumor xenograft with or without radiotherapy and STL127705. J Schematic diagram of drug therapy for HCT116 xenograft model. K Gross images of HCT116 and CNOT7 knockdown HCT116 cell-derived subcutaneous tumors with or without radiotherapy and STL127705. L–N Tumor growth curves (L), tumor volume (M) and tumor weights (N) of HCT116 and CNOT7 knockdown HCT116 cell-derived subcutaneous tumors with or without radiotherapy and STL127705.