Fig. 5: Impact of DNMT1 on brain metastases in breast cancer in mice.
From: DNMT1 modulation of RASSF1A methylation enhances breast cancer brain metastasis
A Tumor growth measurement in mice groups using the IVIS Lumina II imaging system. B Detection of DNMT1 and PCNA expression in mouse brain tissues by Western blotting. C Immunohistochemical analysis of positive expression of DNMT1 and PCNA in mouse brain tissues (scale bar=50 μm). D H&E staining to examine brain metastasis nodules in mice groups (scale bar=50 μm), with black boxes highlighting the brain metastasis nodules. Each group consists of 6 mice; *** indicates statistical significance at P < 0.001 when comparing between groups.
