Fig. 6: Intravenous administration of MSCs attenuates mitochondrial fission in diabetic mice. | Cell Death & Disease

Fig. 6: Intravenous administration of MSCs attenuates mitochondrial fission in diabetic mice.

From: MSCs ameliorates hyperglycemia-induced endothelial injury through modulation of mitochondrial dynamics

Fig. 6: Intravenous administration of MSCs attenuates mitochondrial fission in diabetic mice.The alternative text for this image may have been generated using AI.

A Representative TEM micrographs of mitochondria in aortic endothelial cells from mice of different groups. B Quantification of mitochondrial aspect ratio in aortic endothelial cells from mouse (n = 6 mice/group). Data are shown as means ± SD. *P < 0.05. C, D Representative Western blots and densitometric analysis of indicated proteins expression in aorta of db/m and db/db mice given saline or MSCs transfected with scramble siRNA or with STC1 siRNA (n = 6 mice/group). Data are shown as means ± SD. (*P < 0.05 vs. db/m, &P < 0.05 vs. db/db, #P < 0.05 vs. db/db + MSCs). E–G Representative images of immunohistochemical staining and quantification of positive staining for Drp1-ser616 and p-ERK1/2 staining in sections of aorta from different groups (n = 6 mice/group). Data are shown as means ± SD. *P < 0.05. H, I Representative Western blots and graph of Drp1 of mitochondrial fractions obtained from aorta tissues in each group (n = 6 mice/group). Data are shown as means ± SD. *P < 0.05. Data were analyzed using one-way ANOVA with Tukey’s post hoc test.

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